Performance Profile of Django REST framework
Here is an informative post for Web API developers breaking down the Django REST Framework versus other REST frameworks.
The author argues that, when building high-performance Web APIs, you should focus on the "right" things. The right things being that the framework is mature, well-supported and well-tested.
You should avoid making your decision based on the false belief that smaller = faster. Instead, consider the performance of the application's overall architecture.
This post dispels some popular myths, too, like that you should roll your own framework, and that you should always use a "lightweight" framework.